Novel hydrophilic matrix system with non-uniform drug distribution for zero-order release kinetics
نویسندگان
چکیده
منابع مشابه
One-pot Synthesis and Encapsulation of Hydrophilic Drug in Uniform Microparticles for Controlled Release
The route for single step synthesis and encapsulation of a model hydrophilic drug onto homogeneous microparticles for controlled release applications is described. The microfluidic spray drying technique, able to handle complex fluids, was used to produce uniform particles with adjustable functionality. Here, an aqueous polymeric dispersion of Eudragit NE was used as the controlled release matr...
متن کاملA New Application of Lipid Nanoemulsions as Coating Agent, Providing Zero-Order Hydrophilic Drug Release from Tablets
The objective of the present investigation was to evaluate potential of nanoemulsions as a coating material for the tablets. The nanoemulsion of size less than 100 nm was prepared using a simple and low-energy spontaneous emulsification method. Conventional tablets containing theophylline as a model hydrophilic drug were prepared. The theophylline tablets were coated with the nanoemulsion using...
متن کاملOn the property of for a second-order system with zero diagonal coefficient
Abstract: This paper investigates the problem of whether all trajectories of the system and cross the vertical isocline, which is very important for the existence of periodic solutions and oscillation theory. Sufficient conditions are given for all trajectories to cross the vertical isocline.
متن کاملBainite transformation kinetics Part 2 Non-uniform distribution of carbon
The carbon concentration trapped in films of austenite between parallel platelets of bainite is often found to be much larger than that in the larger blocks of austenite between sheaves of bainite. The effect of this non-uniform distribution of carbon on the overall transformation kinetics of bainite is examined theoretically. It is found that the trapping of carbon in the films of austenite ac...
متن کاملMatrix Tablets: An Effective Way for Oral Controlled Release Drug Delivery
The purpose of this review article is to characterize all of the parameters regarding the types, polymers used, and release kinetics of matrix tablets. Matrix system was the earliest oral extended release platform for medicinal use. Matrix tablets are most commonly used methods to modulate the release profile of drugs. They are much desirable and preferred for such therapy because they o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Controlled Release
سال: 2018
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2018.08.027